For an oocyte to get ready for fertilization and expansion into an embryo, the proper set of genes really should be turned on. Namekawa suspected that this pre-programming in the oocyte genome transpires in several stages — the first a single commencing within the time a woman is born. He thought that chromatin remodeling proteins did Significantly of the get the job done, by shifting spools close to.
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The DNA in the human oocyte encompasses some 15 million nucleosomes — wrapping two times close to every one — forming an arranged composition named chromatin.
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